Seguin is strategically located in South Central Texas on Interstate Highway 10. Thirty minutes east of San Antonio, the tenth largest city in the United States. Austin, the state capital, is conveniently accessible 50 miles to the north by State Highway 123 and Interstate Highway 35. The ports of Houston and Corpus Christi are nearly equal distance from Seguin.

Seguin is home to Texas Lutheran University and several industries, including Alamo Group, SMI Steel, Hexcel and Motorola. The average annual temperature is 67 degrees and the annual average precipitation is 31.9 inches.

As of the 2010 census, the city population was 25,175, making Seguin the fourth largest city in the San Antonio-New Braunfels Metropolitan Statistical Area.

The median income for a household in the city was $31,618, and the median income for a family was $36,931. Males had a median income of $27,007 versus $19,690 for females. The per capita income for the city was $13,740. About 13.2% of families and 17.2% of the population were below the poverty line, including 22.3% of those under age 18 and 13.6% of those age 65 or over.