Abilene is located in Taylor and Jones counties in west central Texas. The population was 117,063 according to the 2010 census making it the twenty-fifth most populous city in the state of Texas. It is the principal city of the Abilene Metropolitan Statistical Area, which had a 2006 estimated population of 158,063. It is the county seat of Taylor County. Dyess Air Force Base is located on the west side of the city.

Abilene is located off Interstate 20, between exits 279 on its western edge and 292 on the east. Abilene is 150 miles (240 km) west of Fort Worth, Texas. The city is looped by I-20 to the north, US 83/84 on the west, and Loop 322 to the east. A railroad divides the city down the center into north and south. The historic downtown area is on the north side of the railroad.

The median income for a household in the city was $33,007, and the median income for a family was $40,028. Males had a median income of $28,078 versus $20,918 for females. The per capita income for the city was $16,577. About 10.9% of families and 15.4% of the population were below the poverty line, including 18.6% of those under age 18 and 9.2% of those age 65 or over.