Florence is located in Florence County, South Carolina. The city is the county seat of Florence County and the hub of the Metropolitan Statistical Area. The area forms the core of the historical “Pee Dee” region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. The 2010 U.S. Census Bureau estimated the city’s population at 37,326.

Florence has blossomed into a strong center for medical care, with three major medical providers McLeod Regional Medical Center, Carolinas Hospital System and HealthSouth. The growth of these providers has led to the transformation of the Florence skyline over the last 10 years, with development for demand with multi-story high-rises as well as community relation projects.